Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2209751 | 0.95 | HRH3 (0.53) | HRH3MCHR1TP53MAPTRECQL | |
| SCHEMBL2210609 | 0.90 | HRH3 (0.58) | HRH3MCHR1NPC1RAB9A | |
| SCHEMBL2208759 | 0.87 | MCHR1 (0.47) | HRH3MCHR1 | |
| SCHEMBL2214389 | 0.86 | HRH3 (0.52) | HRH3MCHR1HCRTR1HCRTR2 | |
| SCHEMBL2206388 | 0.86 | HRH3 (0.58) | HRH3MCHR1 | |
| SCHEMBL2208189 | 0.85 | HRH3 (0.64) | HRH3MCHR1 | |
| SCHEMBL2208886 | 0.85 | HRH3 (0.61) | HRH3MCHR1 | |
| SCHEMBL2212774 | 0.85 | HRH3 (0.47) | HRH3MCHR1 | |
| SCHEMBL2212421 | 0.84 | HRH3 (0.47) | HRH3MCHR1 | |
| SCHEMBL2211215 | 0.84 | HRH3 (0.57) | HRH3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-B1 | QUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | claimed |