Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | POLG | P54098 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14078491 | 1.00 | POLB (0.48) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL15267601 | 0.91 | POLB (0.48) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL23200453 | 0.90 | POLB (0.51) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL12360856 | 0.90 | POLB (0.51) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL66763 | 0.90 | POLB (0.51) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL27267680 | 0.90 | POLB (0.51) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL14512782 | 0.89 | POLB (0.49) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL12015129 | 0.89 | POLB (0.49) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL68614 | 0.89 | POLB (0.49) | POLBLMNAPDE3ACACNA1FALB | |
| SCHEMBL16587688 | 0.87 | POLB (0.48) | POLBLMNAPDE3ACACNA1FALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132227-A2 | AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |