Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214137 | 1.00 | AKT1 (0.42) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL2214139 | 1.00 | AKT1 (0.42) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1348584 | 0.88 | AKT1 (0.49) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1348587 | 0.88 | AKT1 (0.49) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1348589 | 0.88 | AKT1 (0.49) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1348585 | 0.88 | AKT1 (0.49) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1349726 | 0.86 | AKT1 (0.48) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1349731 | 0.86 | AKT1 (0.48) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1349727 | 0.86 | AKT1 (0.48) | AKT1CHUKDYRK3ROCK2MAP4K4 | |
| SCHEMBL1349728 | 0.86 | AKT1 (0.48) | AKT1CHUKDYRK3ROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1947100-B1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT INC (US) | 2011-07-27 | — | — | EP | claimed |
| EP-1947100-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | Targacept, Inc. (US) | 2008-07-23 | — | — | EP | claimed |