Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | FECH | P22830 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211520 | 0.88 | PLK1 (0.53) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2211511 | 0.88 | PLK1 (0.53) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2211496 | 0.88 | PLK1 (0.53) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2211481 | 0.88 | PLK1 (0.53) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2210291 | 0.85 | PLK1 (0.49) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2210303 | 0.85 | PLK1 (0.49) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2213413 | 0.85 | SMN1; SMN2 (0.54) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2213268 | 0.84 | PLK1 (0.48) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL2213252 | 0.84 | PLK1 (0.48) | PLK1HDAC4HDAC1HDAC6HDAC3 | |
| SCHEMBL1634974 | 0.84 | PLK1 (0.42) | PLK1HDAC4HDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | disclosed |