Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22143710 | 0.81 | TSHR (0.45) | TSHRMAPK1NOS1NQO2LMNA | |
| SCHEMBL16089346 | 0.77 | MAPK1 (0.67) | TSHRMAPK1NOS1NQO2LMNA | |
| SCHEMBL16075909 | 0.77 | MAPK1 (0.67) | TSHRMAPK1NOS1NQO2LMNA | |
| SCHEMBL628983 | 0.77 | TSHR (0.67) | TSHRMAPK1NQO2LMNAGAA | |
| Guanidine SCHEMBL27922792 | 0.77 | TSHR (0.64) | TSHRNOS1LMNAGAACES1 | |
| Hydrochloric Acid SCHEMBL2148501 | 0.76 | TSHR (0.64) | TSHRMAPK1NOS1NQO2LMNA | |
| SCHEMBL21262437 | 0.74 | NQO2 (0.41) | MAPK1NOS1NQO2LMNAGAA | |
| SCHEMBL10861088 | 0.73 | MAPK1 (0.72) | TSHRMAPK1NOS1LMNAGAA | |
| SCHEMBL21871 | 0.73 | MAPK1 (0.72) | TSHRMAPK1NOS1LMNAGAA | |
| Acetic Acid SCHEMBL28100034 | 0.73 | TSHR (0.85) | TSHRMAPK1NOS1NQO2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021255174-A1 | SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2021-12-23 | — | — | WO | disclosed |
| WO-2021255086-A1 | SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2021-12-23 | — | — | WO | disclosed |
| WO-2020127685-A1 | AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2020-06-25 | — | — | WO | disclosed |