Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124426 | 0.87 | CBFB (0.57) | CBFBNPC1RAB9ARUNX1CCR1 | |
| SCHEMBL179158 | 0.78 | CBFB (0.65) | CBFBNPC1RAB9ARUNX1SYK | |
| SCHEMBL179145 | 0.73 | CBFB (0.56) | CBFBNPC1RAB9ARUNX1PDPK1 | |
| SCHEMBL179150 | 0.73 | CBFB (0.56) | CBFBNPC1RAB9ARUNX1PDPK1 | |
| SCHEMBL179144 | 0.73 | CBFB (0.56) | CBFBNPC1RAB9ARUNX1PDPK1 | |
| SCHEMBL125168 | 0.70 | CBFB (0.83) | CBFBNPC1RAB9ARUNX1SYK | |
| SCHEMBL179112 | 0.70 | CBFB (0.62) | CBFBNPC1RAB9ARUNX1PDPK1 | |
| SCHEMBL125632 | 0.69 | CBFB (0.82) | CBFBNPC1RAB9ARUNX1SYK | |
| SCHEMBL8738510 | 0.69 | CCR1 (0.54) | CBFBNPC1RAB9ARUNX1SYK | |
| SCHEMBL125696 | 0.67 | CBFB (0.68) | CBFBNPC1RAB9ARUNX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670509-A1 | INHIBITORS OF INV(16) LEUKEMIA | The University of Virginia Patent Foundation (US) | 2020-06-24 | — | — | EP | disclosed |