Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | PRKCH | P24723 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31655675 | 1.00 | FGFR3 (0.61) | FGFR3KDRZAP70PRKD3EGFR | |
| SCHEMBL31655655 | 0.85 | FGFR3 (0.54) | FGFR3KDRZAP70PRKD3EGFR | |
| SCHEMBL22149114 | 0.85 | FGFR3 (0.54) | FGFR3KDRZAP70PRKD3EGFR | |
| SCHEMBL31655639 | 0.85 | FGFR3 (0.54) | FGFR3KDRZAP70PRKD3EGFR | |
| SCHEMBL22149113 | 0.85 | FGFR3 (0.54) | FGFR3KDRZAP70PRKD3EGFR | |
| SCHEMBL22149121 | 0.84 | KDR (0.60) | FGFR3KDRPRKCIFGFR1FGFR2 | |
| SCHEMBL6950873 | 0.80 | ZAP70 (0.79) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL22149692 | 0.80 | FGFR3 (0.50) | FGFR3KDREGFRFGFR1FGFR2 | |
| SCHEMBL31655616 | 0.80 | FGFR3 (0.50) | FGFR3KDREGFRFGFR1FGFR2 | |
| SCHEMBL21554939 | 0.79 | FGFR3 (0.65) | FGFR3KDREGFRFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131674-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |