Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417030 | 0.96 | MAPK14 (0.55) | MAPK14MAPK11CYP3A4CYP2C9BMPR1B | |
| SCHEMBL1386646 | 0.93 | MAPK14 (0.61) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1416913 | 0.92 | MAPK14 (0.62) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1386388 | 0.89 | MAPK14 (0.66) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1384571 | 0.85 | MAPK14 (0.61) | MAPK14MAPK11CYP3A4CYP2C9MAPK13 | |
| SCHEMBL1382843 | 0.84 | MAPK14 (0.56) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL12515027 | 0.84 | MAPK14 (0.52) | MAPK14MAPK11CYP3A4CYP2C9BMPR1B | |
| SCHEMBL14823447 | 0.84 | MAPK14 (0.62) | MAPK14MAPK11CYP3A4CYP2C9MAPK13 | |
| SCHEMBL1383587 | 0.84 | MAPK14 (0.56) | MAPK14MAPK11CYP3A4CYP2C9KIT | |
| SCHEMBL1382334 | 0.83 | MAPK14 (0.58) | MAPK14MAPK11CYP3A4CYP2C9KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-B1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |