Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 7/20 | 0.41 |
| ▸ | ITK | Q08881 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31655614 | 1.00 | FGFR3 (0.49) | FGFR3KDREGFRBTKFGFR1 | |
| SCHEMBL31655616 | 0.88 | FGFR3 (0.50) | FGFR3KDREGFRBTKFGFR1 | |
| SCHEMBL22149692 | 0.88 | FGFR3 (0.50) | FGFR3KDREGFRBTKFGFR1 | |
| SCHEMBL22122045 | 0.83 | FGFR3 (0.55) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL22149125 | 0.81 | FGFR3 (0.58) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL31655653 | 0.81 | FGFR3 (0.58) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL31655628 | 0.81 | FGFR3 (0.55) | FGFR3KDREGFRFGFR1FGFR2 | |
| SCHEMBL22149124 | 0.80 | FGFR3 (0.46) | FGFR3KDREGFRBTKFGFR1 | |
| SCHEMBL31655620 | 0.80 | FGFR3 (0.46) | FGFR3KDREGFRBTKFGFR1 | |
| SCHEMBL22149121 | 0.79 | KDR (0.60) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131674-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |