Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31655631 | 1.00 | FGFR3 (0.48) | FGFR3KDRHPGDEGFRBTK | |
| SCHEMBL31655634 | 0.90 | FGFR3 (0.44) | FGFR3KDRHPGDEGFRBTK | |
| SCHEMBL22149690 | 0.90 | FGFR3 (0.44) | FGFR3KDRHPGDEGFRBTK | |
| SCHEMBL22149126 | 0.89 | FGFR3 (0.43) | FGFR3KDREGFRBTKLMNA | |
| SCHEMBL31655629 | 0.89 | FGFR3 (0.43) | FGFR3KDREGFRBTKLMNA | |
| SCHEMBL22149692 | 0.86 | FGFR3 (0.50) | FGFR3KDRHPGDEGFRBTK | |
| SCHEMBL31655616 | 0.86 | FGFR3 (0.50) | FGFR3KDRHPGDEGFRBTK | |
| SCHEMBL31655652 | 0.84 | FGFR3 (0.53) | FGFR3KDREGFRITKFGFR1 | |
| SCHEMBL22149691 | 0.84 | FGFR3 (0.53) | FGFR3KDREGFRITKFGFR1 | |
| SCHEMBL22149197 | 0.80 | FGFR3 (0.39) | FGFR3KDREGFRBTKTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020131674-A1 | 7-((3,5-DIMETHOXYPHENYL)AMINO)QUINOXALINE DERIVATIVES AS FGFR INHIBITORS FOR TREATING CANCER | ARRAY BIOPHARMA INC. (US) | 2020-06-25 | — | — | WO | disclosed |