Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.69 |
| ▸ | PPARG | P37231 | 7/20 | 0.69 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 2/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147507 | 0.90 | NR1H4 (0.57) | NR1H4PPARGSERPINE1PPARAALDH1A1 | |
| SCHEMBL16148635 | 0.84 | NR1H4 (0.52) | NR1H4PPARGSERPINE1PPARAALDH1A1 | |
| SCHEMBL16147707 | 0.84 | PPARG (0.56) | NR1H4PPARGSERPINE1PPARANPC1 | |
| SCHEMBL16147354 | 0.83 | NR1H4 (0.60) | NR1H4PPARGSERPINE1PPARAPLG | |
| SCHEMBL16148214 | 0.83 | NR1H4 (0.51) | NR1H4PPARGSERPINE1PPARANPC1 | |
| SCHEMBL16147616 | 0.81 | NR1H4 (0.58) | NR1H4PPARGPPARAALDH1A1NPC1 | |
| SCHEMBL16148752 | 0.81 | NR1H4 (0.52) | NR1H4PPARGSERPINE1PPARARAB9A | |
| SCHEMBL16147579 | 0.81 | PLG (0.68) | NR1H4NPC1RAB9AATMPLG | |
| SCHEMBL16160861 | 0.80 | PLG (0.51) | NR1H4PPARGSERPINE1PPARAALDH1A1 | |
| SCHEMBL16149461 | 0.79 | NR1H4 (0.50) | NR1H4PPARGSERPINE1PPARAPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132700-A1 | METHODS OF USING INHIBITORS OF SREBP IN COMBINATION WITH NICLOSAMIDE AND ANALOGS THEREOF | Fgh Biotech Inc. (US) | 2020-06-25 | — | — | WO | disclosed |