Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.50 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123392 | 0.92 | TTK (0.51) | TTKPTK6KDM1AHDAC1 | |
| SCHEMBL30171705 | 0.92 | TTK (0.51) | TTKPTK6KDM1AHDAC1 | |
| SCHEMBL22122845 | 0.91 | TTK (0.50) | TTKPTK6KDM1AHDAC1MAPKAPK5 | |
| SCHEMBL22124603 | 0.91 | TTK (0.50) | TTKPTK6KDM1AHDAC1PTK2 | |
| SCHEMBL30171597 | 0.91 | TTK (0.50) | TTKPTK6KDM1AHDAC1PTK2 | |
| SCHEMBL30172072 | 0.91 | TTK (0.52) | TTKPTK6MAPKAPK5PTK2BRAF | |
| SCHEMBL22122908 | 0.91 | TTK (0.52) | TTKPTK6MAPKAPK5PTK2BRAF | |
| SCHEMBL30172068 | 0.88 | FYN (0.52) | TTK | |
| SCHEMBL22122904 | 0.88 | FYN (0.52) | TTK | |
| SCHEMBL22139065 | 0.88 | MAPKAPK5 (0.54) | TTKPTK6MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020126956-A1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |