Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.35 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22152193 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2GAASTAT3NPSR1POLB | |
| SCHEMBL22153087 | 0.82 | KAT2B (0.38) | SMN1; SMN2GAAKAT2B | |
| SCHEMBL22155667 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2GAASTAT3NPSR1POLB | |
| SCHEMBL22153090 | 0.81 | KAT2B (0.37) | SMN1; SMN2GAAKAT2B | |
| SCHEMBL22155669 | 0.81 | KAT2B (0.37) | SMN1; SMN2GAAKAT2B | |
| SCHEMBL22152194 | 0.81 | KAT2B (0.37) | SMN1; SMN2GAAKAT2B | |
| SCHEMBL10095347 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2GAASTAT3NPSR1POLB | |
| SCHEMBL22152181 | 0.77 | KDM1A (0.44) | SMN1; SMN2GAASTAT3NPSR1KRAS | |
| SCHEMBL22156316 | 0.77 | KAT2B (0.45) | GAAKAT2BMEN1KMT2A | |
| SCHEMBL22122433 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2GAASTAT3NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200197391-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | KRAS, NRAS, HRAS | SMN1; SMN2 4348/4885GAA 3216/4885KAT2B 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.