SCHEMBL22158409

SCHEMBL22158409

N#Cc1c(-n2c3ccccc3c3ccc(-c4ccccc4)cc32)cc(-c2c(F)cccc2F)cc1-n1c2ccccc2c2ccc(-c3ccccc3)cc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE9A O76083 2/20 0.35
PDE1C Q14123 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
HIF1A Q16665 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
GRIA2 P42262 1/20 0.33
GRIA4 P48058 1/20 0.33
HTR3A P46098 1/20 0.33
PARP1 P09874 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
DYRK1A Q13627 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
PTGES O14684 1/20 0.32
PGR P06401 1/20 0.32
KDM4A O75164 1/20 0.32
KDM5B Q9UGL1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22156500 0.96 SMN1; SMN2 (0.36) SMN1; SMN2HIF1ACYP11B1CYP11B2GRIA2
SCHEMBL23348279 0.94 SMN1; SMN2 (0.33) PDE9APDE1CSMN1; SMN2HIF1ACYP11B1
SCHEMBL22156486 0.93 PDE9A (0.41) PDE9APDE1CSMN1; SMN2HIF1AKDM4E
SCHEMBL22156574 0.93 PDE9A (0.35) PDE9APDE1CSMN1; SMN2HIF1ACYP11B1
SCHEMBL22156492 0.91 PDE9A (0.38) PDE9APDE1CSMN1; SMN2HIF1AGRIA2
SCHEMBL22156472 0.91 PDE9A (0.34) PDE9APDE1CSMN1; SMN2HIF1ACYP11B1
SCHEMBL22156701 0.90 CYP1A2 (0.34) PDE9APDE1CSMN1; SMN2HIF1AKDM4E
SCHEMBL22156396 0.90 MAPT (0.36) PDE9APDE1CCYP11B2HTR3APARP1
SCHEMBL22157017 0.90 PDE9A (0.35) PDE9APDE1CSMN1; SMN2HIF1ACYP11B1
SCHEMBL22155937 0.89 PDE9A (0.36) PDE9APDE1CSMN1; SMN2HIF1ACYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200203628-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2020-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200203628-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, ORC3, OR51E2 PDE9A 4546/4885PDE1C 4637/4885SMN1; SMN2 4592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.