Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 12/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123273 | 0.93 | TTK (0.50) | TTKPTK6MAPKAPK5SYKMEN1 | |
| SCHEMBL25173790 | 0.93 | TTK (0.48) | TTKPTK6MAPKAPK5SYKAURKA | |
| SCHEMBL30177930 | 0.92 | SYK (0.51) | TTKPTK6MAPKAPK5SYK | |
| SCHEMBL22122930 | 0.91 | TTK (0.49) | TTKPTK6MAPKAPK5SYK | |
| SCHEMBL22123505 | 0.90 | TTK (0.46) | TTKPTK6MAPKAPK5SYKAURKA | |
| SCHEMBL22160262 | 0.89 | TTK (0.49) | TTKPTK6MAPKAPK5AURKA | |
| SCHEMBL30171879 | 0.88 | TTK (0.44) | TTKPTK6MAPKAPK5SYKAURKA | |
| SCHEMBL24870730 | 0.88 | TTK (0.44) | TTKPTK6MAPKAPK5SYKAURKA | |
| SCHEMBL24104678 | 0.87 | TTK (0.44) | TTKPTK6MAPKAPK5GAAMAPT | |
| SCHEMBL30168196 | 0.87 | TTK (0.44) | TTKPTK6MAPKAPK5GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| WO-2020126953-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | disclosed |