Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 16/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.56 |
| ▸ | KDM1A | O60341 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215179 | 1.00 | GRIA4 (0.57) | GRIA4GRIA2KCNH2KDM1AMAOA | |
| SCHEMBL2215515 | 0.87 | GRIA2 (0.56) | GRIA4GRIA2KCNH2 | |
| SCHEMBL2215518 | 0.87 | GRIA2 (0.56) | GRIA4GRIA2KCNH2 | |
| SCHEMBL12513978 | 0.87 | GRIA2 (0.56) | GRIA4GRIA2KCNH2 | |
| SCHEMBL12514031 | 0.83 | KDM1A (0.54) | GRIA2KCNH2KDM1AMAOAMAOB | |
| SCHEMBL2215911 | 0.83 | KDM1A (0.54) | GRIA2KCNH2KDM1AMAOAMAOB | |
| SCHEMBL2215913 | 0.83 | KDM1A (0.54) | GRIA2KCNH2KDM1AMAOAMAOB | |
| SCHEMBL2213363 | 0.83 | GRIA2 (0.77) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL12513937 | 0.83 | GRIA2 (0.77) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL2213367 | 0.83 | GRIA2 (0.77) | GRIA4GRIA2KCNH2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848695-B1 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LTD (GB) | 2011-07-27 | — | — | EP | claimed |