Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.80 |
| ▸ | CCND1 | P24385 | 17/20 | 0.80 |
| ▸ | CDK2 | P24941 | 15/20 | 0.80 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.80 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.80 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.80 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.80 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.80 |
| ▸ | CDK1 | P06493 | 3/20 | 0.80 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.80 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.80 |
| ▸ | CDK9 | P50750 | 2/20 | 0.80 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.80 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.80 |
| ▸ | FYN | P06241 | 1/20 | 0.80 |
| ▸ | CSF1R | P07333 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.80 |
| ▸ | MARK3 | P27448 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Narazaciclib SCHEMBL30418763 | 0.89 | CDK4 (1.00) | CDK4CCND1CDK2CCNA2FGFR1 | |
| Narazaciclib SCHEMBL10050883 | 0.89 | CDK4 (1.00) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22165064 | 0.88 | CDK4 (0.63) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL14955943 | 0.88 | CDK4 (0.98) | CDK4CCND1CDK2CCNA2FGFR1 | |
| Narazaciclib SCHEMBL14955407 | 0.88 | CDK4 (0.98) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL14954855 | 0.88 | CDK4 (0.97) | CDK4CCND1CDK2CCNA2FGFR1 | |
| Narazaciclib SCHEMBL26685640 | 0.87 | CDK4 (0.92) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL24618846 | 0.87 | CDK4 (0.92) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL10050960 | 0.87 | CDK4 (0.82) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL22860031 | 0.86 | CDK4 (0.84) | CDK4CCND1CDK2CCNA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220220103-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. | 2022-07-14 | — | — | US | claimed |
| US-20220220103-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. | 2022-07-14 | — | — | US | disclosed |
| US-20220220103-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. | 2022-07-14 | — | — | US | disclosed |
| WO-2020140053-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220220103-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | CDK2, CDK1, CCNK | CDK4 9/4885CCND1 51/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.