Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21736642 | 0.90 | KLKB1 (0.44) | KLKB1NR1H2 | |
| SCHEMBL21736734 | 0.87 | KLKB1 (0.41) | KLKB1 | |
| SCHEMBL24918421 | 0.86 | KLKB1 (0.43) | KLKB1NR1H2 | |
| SCHEMBL23830240 | 0.81 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL21736873 | 0.77 | KLKB1 (0.36) | KLKB1NR1H2 | |
| SCHEMBL23769461 | 0.76 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL21736732 | 0.75 | KLKB1 (0.40) | KLKB1NR1H2 | |
| SCHEMBL21713012 | 0.74 | NR1H2 (0.50) | KLKB1NR1H2 | |
| SCHEMBL22166243 | 0.73 | KLKB1 (0.59) | KLKB1 | |
| SCHEMBL21736884 | 0.73 | KLKB1 (0.44) | KLKB1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | KLKB1, KLK1, KLK5 | KLKB1 1/4885NR1H2 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.