⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910040 | 0.84 | TRIM24 (0.31) | — | |
| Hydrochloric Acid SCHEMBL1771294 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL27001775 | 0.80 | — | — | |
| SCHEMBL6434771 | 0.74 | TRIM24 (0.36) | — | |
| SCHEMBL3619632 | 0.71 | CYP1A2 (0.61) | — | |
| SCHEMBL17435216 | 0.70 | — | — | |
| SCHEMBL1160928 | 0.69 | — | — | |
| SCHEMBL1431864 | 0.69 | — | — | |
| SCHEMBL232122 | 0.69 | — | — | |
| SCHEMBL27583411 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-56005461-A | — | — | None | — | — | JP | disclosed |
| JP-56002984-A | — | — | None | — | — | JP | disclosed |
| JP-56007765-A | — | — | None | — | — | JP | disclosed |
| EP-3998260-B1 | SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-116969904-A | Compounds useful as autophagy modulators, methods of preparation and uses thereof | 微境生物医药科技(上海)有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-111148740-B | Compounds useful as autophagy modulators, methods of preparation and uses thereof | 微境生物医药科技(上海)有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-109369635-B | Compound or pharmaceutically acceptable salt thereof, application thereof and pharmaceutical composition | 赛克里翁治疗有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230159492-A1 | FERROPTOSIS INHIBITORS - DIARYLAMINE PARA-ACETAMIDES | Sironax Ltd. (KY) | 2023-05-25 | — | — | US | disclosed |
| US-20230106002-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. | 2023-04-06 | — | — | US | disclosed |
| CN-109384778-B | Use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of a disease, health condition or disorder | 赛克里翁治疗有限公司 | 2022-12-13 | — | — | CN | disclosed |
| EP-1571148-A1 | 3-PHENYL-CINNOLINE HOMOLOGUE AND ANTITUMOR AGENT CONTAINING THE SAME | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-09-07 | — | — | EP | disclosed |
| EP-1259510-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001066544-A2 | TRICYCLIC DIHYDROPYRAZOLONE AND TRICYCLIC DIHYDROISOXAZOLONE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2001-09-13 | — | — | WO | disclosed |
| EP-0059291-B1 | ANTIHYPERTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-27 | — | — | EP | disclosed |
| US-4365063-A | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-12-21 | — | — | US | disclosed |
| EP-0059291-A1 | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-08 | — | — | EP | disclosed |
| US-4321384-A | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |
| JP-S567765-A | 4,4'-METHYLENEBIS-(1-SUBSTITUTED-3-PHENYLAMINO-5-OXO-3,4-DEHYDROPIPERIDINE) DERIVATIVE | TAMURA YASUMITSU | 1981-01-27 | — | — | JP | disclosed |
| JP-S565461-A | 1-SUBSTITUTED-3-ANILINO-4-DIALKYLAMINOMETHYL-5-OXO-3,4- DEHYDROPIPERIDINE | TAMURA YASUMITSU | 1981-01-20 | — | — | JP | disclosed |
| JP-S562984-A | 1,2,3,5,6,11-HEXAHYDRO-5-PHENYL-4H-PYRIDO(3,4-B)(1,5)BENZODIAZEPIN-4-ONE DERIVATIVE | TAMURA YASUMITSU | 1981-01-13 | — | — | JP | disclosed |