⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18963556 | 1.00 | — | — | |
| SCHEMBL14205388 | 0.81 | — | — | |
| SCHEMBL18603115 | 0.81 | — | — | |
| SCHEMBL18581293 | 0.81 | — | — | |
| SCHEMBL14737560 | 0.80 | — | — | |
| SCHEMBL2297447 | 0.80 | — | — | |
| SCHEMBL20673187 | 0.80 | — | — | |
| SCHEMBL29771365 | 0.78 | — | — | |
| SCHEMBL28823871 | 0.78 | — | — | |
| SCHEMBL22260165 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674409-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE | Alnylam Pharmaceuticals, Inc. (US) | 2020-07-01 | — | — | EP | disclosed |
| EP-2723758-B1 | ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSTIONS AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |
| EP-2836595-B1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |