SCHEMBL22172243

SCHEMBL22172243

Cc1nc2c(F)cc(-c3nc(Nc4ccc(C(=O)N5CCN(C)CC5)c(F)c4)ncc3F)cc2n1C(C)C

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 18/20 0.62
CDK2 P24941 11/20 0.62
CDK1 P06493 9/20 0.62
CCNB1 P14635 6/20 0.62
CCND3 P30281 3/20 0.62
CCNA2 P20248 1/20 0.62
KDR P35968 1/20 0.62
CCNE1 P24864 5/20 0.61
HDAC1 Q13547 2/20 0.59
HDAC6 Q9UBN7 2/20 0.59
HDAC3 O15379 1/20 0.59
HDAC10 Q969S8 1/20 0.59
CDK6 Q00534 12/20 0.59
CDK9 P50750 4/20 0.59
CDK7 P50613 3/20 0.59
EGFR P00533 1/20 0.58
CCND1 P24385 2/20 0.56
CSF1R P07333 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28703117 0.92 CDK4 (0.60) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL22172176 0.92 CDK4 (0.67) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL22172186 0.92 CDK4 (0.61) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL28702269 0.91 CDK4 (0.60) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL28703105 0.90 CDK4 (0.59) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL19968032 0.86 CDK4 (0.63) CDK4CDK2CDK1CCNB1CCNE1
SCHEMBL19968038 0.86 CDK4 (0.64) CDK4CDK2CDK1CCNB1CCNE1
SCHEMBL22172189 0.85 CDK4 (0.65) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL28709613 0.85 CDK4 (0.53) CDK4CDK2CDK1CCNB1CCND3
SCHEMBL22163901 0.84 CDK4 (0.63) CDK4CDK2CDK1CCNB1CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020135507-A1 POLYSUBSTITUTED ANILINOPYRIMIDINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF 杭州百新生物医药科技有限公司 2020-07-02 WO disclosed