Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21934645 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL10092700 | 0.91 | HRH3 (0.41) | HRH3TSHRCYP2D6KCNH2 | |
| SCHEMBL22456342 | 0.84 | HRH3 (0.41) | HRH3TSHR | |
| SCHEMBL14453902 | 0.84 | HRH3 (0.41) | HRH3TSHRCYP2D6KCNH2 | |
| SCHEMBL14355433 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL18976856 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL24172542 | 0.83 | HRH3 (0.38) | HRH3TSHRCYP2D6KCNH2 | |
| SCHEMBL23384368 | 0.83 | KDM4E (0.42) | KDM4EALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL13744835 | 0.83 | KDM4E (0.42) | KDM4EALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL10092688 | 0.83 | HRH3 (0.42) | HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140052-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |
| WO-2020140054-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |