Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38658807 | 0.96 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12849555 | 0.92 | HTR2C (0.56) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL22184883 | 0.83 | HTR2C (0.54) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL22184379 | 0.80 | HTR2C (0.54) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL22175037 | 0.80 | HTR2C (0.54) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4431805 | 0.79 | HTR2C (0.72) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL15743850 | 0.79 | SMN1; SMN2 (0.48) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL8290690 | 0.79 | SMN1; SMN2 (0.48) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL16467962 | 0.79 | HTR2C (0.76) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3652770 | 0.79 | HTR2C (0.76) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140055-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |
| WO-2020140054-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |