SCHEMBL2218287

SCHEMBL2218287

CN(C)c1ccc(C=CC(N)=O)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 1/20 0.72
TLR9 Q9NR96 2/20 0.58
CRHBP P24387 1/20 0.58
CRHR2 Q13324 1/20 0.58
MAPT P10636 5/20 0.57
KMT2A Q03164 4/20 0.56
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56
HDAC3 O15379 2/20 0.56
HDAC4 P56524 2/20 0.56
HDAC1 Q13547 2/20 0.56
HDAC7 Q8WUI4 2/20 0.56
HDAC2 Q92769 2/20 0.56
HDAC10 Q969S8 2/20 0.56
HDAC11 Q96DB2 2/20 0.56
HDAC8 Q9BY41 2/20 0.56
HDAC6 Q9UBN7 2/20 0.56
HDAC9 Q9UKV0 2/20 0.56
HDAC5 Q9UQL6 2/20 0.56
CASP3 P42574 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13748345 1.00 HSD17B3 (0.72) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL13067861 0.95 HSD17B3 (0.66) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL9864598 0.90 HSD17B3 (0.60) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL814396 0.84 HSD17B3 (1.00) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL814395 0.84 HSD17B3 (1.00) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL3050207 0.84 HSD17B3 (1.00) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL1450230 0.83 F3 (0.52) HSD17B3MAPTHDAC3HDAC4HDAC1
SCHEMBL381477 0.82 HSD17B3 (0.75) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL2029091 0.82 HSD17B3 (0.75) HSD17B3TLR9CRHBPCRHR2MAPT
SCHEMBL3732489 0.82 HSD17B3 (0.75) HSD17B3TLR9CRHBPCRHR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US claimed
CN-114957053-B Oxoethylene compound or pharmaceutically acceptable salt thereof, preparation method and application thereof, pharmaceutical composition and application thereof 中国医学科学院医药生物技术研究所 2023-12-22 CN disclosed
CN-116457023-A antibody-TLR agonist conjugates, methods and uses thereof AMBRX公司 2023-07-18 CN disclosed
CN-114957053-A Oxoethylene compound or pharmaceutically acceptable salt thereof, preparation method and application thereof, pharmaceutical composition and application thereof 中国医学科学院医药生物技术研究所 2022-08-30 CN disclosed
EP-2666814-B1 ELECTRICALLY CONDUCTIVE RUBBER ELASTOMER, CHARGING MEMBER, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2018-03-14 EP disclosed
EP-2490077-B1 ELECTRIFICATING MEMBER AND ELECTROPHOTOGRAPHIC DEVICE CANON KK (JP) 2014-10-01 EP disclosed
US-8750762-B2 Charging member with vulcanized rubber, and electrophotographic apparatus including the charging member CANON KABUSHIKI KAISHA (JP) 2014-06-10 US disclosed
EP-2666814-A1 ELECTRICALLY CONDUCTIVE RUBBER ELASTOMER, CHARGING MEMBER, AND ELECTROPHOTOGRAPHIC APPARATUS Canon Kabushiki Kaisha (JP) 2013-11-27 EP disclosed
US-8491994-B2 Conductive rubber elastic material, charging member and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2013-07-23 US disclosed
US-8367775-B2 Modified conjugated diene-vinyl aromatic copolymer and method for manufacturing the same CHI MEI CORPORATION (TW) 2013-02-05 US disclosed
US-20110176833-A1 CHARGING MEMBER AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2011-07-21 US disclosed
US-6414013-B1 KINASE INHIBITORS; ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-07-02 US disclosed
US-5115006-A Modified conjugated diene rubber with alkali or alkaline earth metals, and amine NIPPON ZEON CO., LTD. (JP) 1992-05-19 US disclosed
US-4950719-A LOW TEMPERATURE VIBRATION INSULATOR NIPPON ZEON CO., LTD. (JP) 1990-08-21 US disclosed
EP-0150479-B1 PROCESS FOR MODIFYING CONJUGATED DIENE POLYMERS NIPPON ZEON CO., LTD. (JP) 1990-06-13 EP disclosed
US-4929679-A BUTADIENE-STYRENE COPOLYMERS BLENDS WITH NATURAL RUBBERS OR POLYISOPRENE, WEAR RESISTANCE NIPPON ZEON CO., LTD. (JP) 1990-05-29 US disclosed
US-4786680-A NONSKIDDING, NATURAL RUBBER, POLYISOPRENE, SBR, HALOGENATED BUTYL RUBBER THE YOKOHAMA RUBBER CO., LTD. (JP) 1988-11-22 US disclosed
US-4761358-A Electrostatographic encapsulated toner FUJI PHOTO FILM CO., LTD. (JP) 1988-08-02 US disclosed
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US disclosed
EP-0150479-A2 Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1985-08-07 EP disclosed