Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215952 | 0.85 | HDAC8 (0.63) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL1148475 | 0.84 | MEN1 (0.78) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL2217357 | 0.84 | HDAC8 (0.64) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL12436028 | 0.83 | MAPT (0.58) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL6813580 | 0.82 | MEN1 (0.82) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL2217242 | 0.80 | MAPT (0.56) | KMT2AMEN1MAPTHTTLMNA | |
| SCHEMBL17507527 | 0.80 | MAPT (0.56) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL2217659 | 0.79 | MAPT (0.50) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL2033537 | 0.79 | MEN1 (0.74) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL17507526 | 0.77 | KMT2A (0.63) | KMT2AMEN1MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351731-B1 | A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE | INST MED BIOTECHNOLOGY CAMS (CN) | 2016-02-10 | — | — | EP | disclosed |
| US-8710098-B2 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Chinese Academy of Medical Science (CN) | 2014-04-29 | — | — | US | disclosed |
| EP-2351731-A1 | A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE | Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences (CN) | 2011-08-03 | — | — | EP | disclosed |
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | KMT2A 964/4885MEN1 4747/4885MAPT 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.