Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 14/20 | 0.42 |
| ▸ | CSF1R | P07333 | 8/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22184334 | 0.82 | EGFR (0.41) | FGFR4EGFRCSF1RTNK2MAP4K2 | |
| SCHEMBL30883472 | 0.79 | FGFR4 (0.45) | FGFR4EGFRTNK2MAP4K2MEN1 | |
| SCHEMBL27225133 | 0.79 | FGFR4 (0.45) | FGFR4EGFRTNK2MAP4K2MEN1 | |
| SCHEMBL4404778 | 0.79 | FGFR4 (0.40) | FGFR4EGFRCSF1RFGFR1FGFR2 | |
| SCHEMBL4398695 | 0.79 | FGFR4 (0.56) | FGFR4FGFR1PDGFRBFGFR2FGFR3 | |
| SCHEMBL4242965 | 0.78 | EGFR (0.43) | FGFR4EGFRMEN1KMT2AKDM4E | |
| SCHEMBL22184683 | 0.75 | EGFR (0.61) | EGFRCSF1RKDR | |
| SCHEMBL25046006 | 0.74 | EGFR (0.60) | EGFRCSF1R | |
| SCHEMBL16071531 | 0.74 | FGFR4 (0.74) | FGFR4EGFRCSF1RFGFR1PDGFRB | |
| SCHEMBL4404529 | 0.74 | FGFR1 (0.55) | FGFR4FGFR1PDGFRBFGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230048132-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. | 2023-02-16 | — | — | US | disclosed |
| WO-2020140055-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | SPV THERAPEUTICS INC. (US) | 2020-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230048132-A1 | CYCLIN-DEPENDENT KINASE INHIBITORS | CDK2, CDK1, CCNK | FGFR4 2910/4885EGFR 1698/4885CSF1R 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.