Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22184876 | 0.94 | IDH1 (0.77) | IDH1 | |
| SCHEMBL22184838 | 0.91 | IDH1 (0.81) | IDH1 | |
| SCHEMBL17814487 | 0.89 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19741887 | 0.89 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17814463 | 0.87 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17814454 | 0.87 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17814195 | 0.87 | IDH1 (1.00) | IDH1 | |
| SCHEMBL21466836 | 0.87 | IDH1 (1.00) | IDH1 | |
| SCHEMBL21466837 | 0.87 | IDH1 (0.80) | IDH1 | |
| SCHEMBL19741836 | 0.85 | IDH1 (1.00) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3226688-B1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES | MERCK SHARP & DOHME (US) | 2020-07-01 | — | — | EP | disclosed |