Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28593946 | 0.99 | AKT1 (0.44) | AKT1PIM1PIM2HRH4CHEK1 | |
| Hydrochloric Acid SCHEMBL28593943 | 0.99 | AKT1 (0.44) | AKT1PIM1PIM2HRH4CHEK1 | |
| SCHEMBL28603240 | 0.80 | KDM4E (0.41) | CHEK1CNR2 | |
| SCHEMBL28603239 | 0.80 | KDM4E (0.41) | CHEK1CNR2 | |
| SCHEMBL22186373 | 0.80 | POLB (0.56) | AKT1CNR2 | |
| SCHEMBL22186781 | 0.80 | POLB (0.56) | AKT1CNR2 | |
| Hydrochloric Acid SCHEMBL28601513 | 0.79 | POLB (0.55) | AKT1CNR2 | |
| Hydrochloric Acid SCHEMBL28597330 | 0.79 | POLB (0.55) | AKT1CNR2 | |
| Hydrochloric Acid SCHEMBL28597331 | 0.79 | POLB (0.55) | AKT1CNR2 | |
| SCHEMBL22186381 | 0.75 | PTGS1 (0.47) | PIM1PIM2HRH4DOT1LCAMK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020138271-A1 | HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2020-07-02 | — | — | WO | disclosed |