Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 4/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244769 | 0.90 | STIM1 (0.40) | STIM1ORAI1KCNH2ATRFFAR4 | |
| SCHEMBL15258900 | 0.82 | STIM1 (0.52) | STIM1ORAI1KCNH2ATRFFAR4 | |
| SCHEMBL12155516 | 0.81 | ATR (0.44) | STIM1ORAI1KCNH2ATRFFAR4 | |
| SCHEMBL12241480 | 0.76 | ATR (0.45) | STIM1ORAI1KCNH2ATRALOX15 | |
| SCHEMBL12241471 | 0.74 | NPC1 (0.52) | STIM1ORAI1KCNH2ALOX15KDM4E | |
| SCHEMBL14225954 | 0.73 | STIM1 (0.53) | STIM1ORAI1KCNH2ATRFFAR4 | |
| SCHEMBL12155602 | 0.72 | IL2 (0.48) | STIM1ORAI1KCNH2ATRFFAR4 | |
| SCHEMBL12155876 | 0.71 | STIM1 (0.55) | STIM1ORAI1DYRK3DYRK1ADYRK2 | |
| SCHEMBL12241474 | 0.71 | NPC1 (0.53) | STIM1ORAI1DYRK1AKDM4EALDH1A1 | |
| SCHEMBL16572575 | 0.71 | ATR (0.43) | STIM1ORAI1KCNH2ATRFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703722-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2020-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703722-B2 | Compounds that modulate intracellular calcium | ORAI1, SARAF, RYR2 | STIM1 17/4885ORAI1 1/4885KCNH2 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.