Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.52 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681917 | 0.92 | KDM2B (0.45) | KDM2BPHF8HRH3HRH4CHRM3 | |
| SCHEMBL12247669 | 0.88 | PHF8 (0.49) | KDM2BPHF8KDM4CQPCTUSP30 | |
| SCHEMBL22302587 | 0.85 | HRH3 (0.43) | KDM2BHRH3HRH4CHRM3NCF1 | |
| SCHEMBL13681927 | 0.83 | KCNH2 (0.42) | KDM2BPHF8HRH3CHRM3KDM4C | |
| SCHEMBL22185811 | 0.80 | KDM2B (0.49) | KDM2BPHF8HRH3HRH4CHRM3 | |
| SCHEMBL13681751 | 0.77 | TLR9 (0.39) | KDM2BPHF8HRH3USP30TLR9 | |
| SCHEMBL13681754 | 0.75 | PHF8 (0.37) | PHF8HRH3HRH4TLR9TLR8 | |
| SCHEMBL30716669 | 0.75 | KDM2B (0.57) | KDM2BPHF8KDM4CMTOR | |
| SCHEMBL23206352 | 0.74 | HRH3 (0.36) | KDM2BHRH3HRH4CHRM3QPCT | |
| SCHEMBL13681766 | 0.73 | HRH3 (0.39) | PHF8HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020141439-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-09 | — | — | WO | disclosed |