Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | STK4 | Q13043 | 1/20 | 0.46 |
| ▸ | STK3 | Q13188 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30828927 | 0.88 | KCNH2 (0.52) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL22191580 | 0.88 | KCNH2 (0.52) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL16332173 | 0.87 | GRIN2B (0.53) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL16332190 | 0.87 | FYN (0.55) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL22216100 | 0.82 | KCNH2 (0.47) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL31271880 | 0.82 | KCNH2 (0.47) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL16331705 | 0.82 | GAK (0.53) | KCNH2ALDH1A1PARP1FYNKDM4E | |
| SCHEMBL16331757 | 0.79 | PIK3CA (0.59) | KCNH2PARP1TYK2 | |
| SCHEMBL16331759 | 0.78 | FYN (0.57) | KCNH2ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL24141207 | 0.77 | MTOR (0.48) | KCNH2FYNJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142557-A1 | IRREVERSIBLE INHIBITORS OF MENIN-MLL INTERACTION | BIOMEA FUSION, LLC (US) | 2020-07-09 | — | — | WO | disclosed |