Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.38 |
| ▸ | USP2 | O75604 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.37 |
| ▸ | CASP1 | P29466 | 6/20 | 0.35 |
| ▸ | CASP7 | P55210 | 6/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200598 | 0.92 | ERN1 (0.38) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200350 | 0.88 | USP2 (0.38) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200338 | 0.87 | ERN1 (0.41) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200601 | 0.86 | ERN1 (0.43) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200356 | 0.84 | ERN1 (0.41) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL25035568 | 0.83 | ERN1 (0.45) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200798 | 0.83 | ERN1 (0.41) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200353 | 0.83 | ERN1 (0.40) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200795 | 0.83 | ERN1 (0.40) | ERN1CYP1A2USP2CYP3A4MEN1 | |
| SCHEMBL22200457 | 0.83 | ERN1 (0.42) | ERN1CYP1A2USP2CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |