Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551707 | 0.82 | PIK3CA (0.48) | PIK3CAMTOR | |
| SCHEMBL25035419 | 0.77 | BRAF (0.46) | PIK3CA | |
| SCHEMBL22190944 | 0.75 | CCNE1 (0.41) | — | |
| SCHEMBL14932667 | 0.70 | PAK1 (0.47) | PIK3CAMTOREGFRFGFR1SRC | |
| SCHEMBL14932655 | 0.69 | PAK1 (0.62) | PIK3CAMTOR | |
| SCHEMBL26930657 | 0.68 | BRAF (0.64) | EGFRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL31338489 | 0.68 | BRAF (0.64) | EGFRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL23884992 | 0.68 | BTK (0.48) | PIK3CAMTORFGFR1SRCFGFR4 | |
| SCHEMBL22171276 | 0.68 | NUAK1 (0.59) | PIK3CAFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22190881 | 0.67 | FGFR1 (0.44) | EGFRFGFR1SRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |