Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29356090 | 1.00 | ERN1 (0.52) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22190949 | 0.92 | ERN1 (0.53) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL25035621 | 0.90 | ERN1 (0.55) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22200724 | 0.89 | ERN1 (0.46) | ERN1MAPK8MAPK10MAPK9SYK | |
| SCHEMBL22200760 | 0.87 | ERN1 (0.51) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22191326 | 0.87 | ERN1 (0.51) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22200759 | 0.87 | ERN1 (0.51) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22200754 | 0.87 | ERN1 (0.55) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL22200810 | 0.87 | ERN1 (0.44) | ERN1BRAFMAPK8MAPK10MAPK9 | |
| SCHEMBL29356354 | 0.87 | ERN1 (0.44) | ERN1BRAFMAPK8MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |