Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 8/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5061885 | 0.81 | PIM1 (0.38) | PIK3CAMTORADORA3ADORA2AADORA2B | |
| SCHEMBL29355878 | 0.81 | PIM1 (0.38) | PIK3CAMTORADORA3ADORA2AADORA2B | |
| SCHEMBL31532094 | 0.80 | FGFR1 (0.56) | PIK3CAFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22191154 | 0.79 | CDK4 (0.33) | PIK3CA | |
| SCHEMBL29355635 | 0.79 | CDK4 (0.33) | PIK3CA | |
| SCHEMBL14301174 | 0.77 | BTK (0.46) | PIK3CAFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL1897414 | 0.75 | PIK3CA (0.58) | PIK3CAMTOR | |
| SCHEMBL22200749 | 0.75 | PIK3CA (0.56) | PIK3CAFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL5266289 | 0.74 | CDK4 (0.57) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL4283863 | 0.72 | PIK3CA (0.48) | PIK3CAFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |