Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.63 |
| ▸ | FYN | P06241 | 6/20 | 0.53 |
| ▸ | SRC | P12931 | 6/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888131 | 0.89 | EGFR (0.59) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL20605393 | 0.89 | EGFR (0.78) | EGFRERBB2FYNSRC | |
| SCHEMBL24168145 | 0.87 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL20780826 | 0.87 | EGFR (0.59) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL20780822 | 0.87 | EGFR (0.59) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL22076917 | 0.86 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL20780780 | 0.86 | ERBB2 (0.56) | EGFRERBB2 | |
| SCHEMBL20780779 | 0.84 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL29025879 | 0.84 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL30478678 | 0.84 | EGFR (0.83) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3677583-A1 | NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2020-07-08 | — | — | EP | disclosed |