SCHEMBL22203239

SCHEMBL22203239

Cc1cc(F)ccc1Oc1cc(Cl)c(C(F)(F)F)cc1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 4/20 0.45
SCN10A Q9Y5Y9 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29435931 1.00 SCN8A (0.45) SCN8ASCN10A
SCHEMBL22203096 0.95 SCN8A (0.45) SCN8ASCN10A
SCHEMBL30532297 0.95 SCN8A (0.45) SCN8ASCN10A
SCHEMBL22203245 0.90 SCN8A (0.45) SCN8ASCN10A
SCHEMBL29435962 0.90 SCN8A (0.45) SCN8ASCN10A
SCHEMBL22203242 0.88 SCN8A (0.46) SCN8ASCN10A
SCHEMBL29435943 0.88 SCN8A (0.46) SCN8ASCN10A
SCHEMBL30532310 0.85 SCN8A (0.45) SCN8ASCN10A
SCHEMBL22203099 0.85 SCN8A (0.45) SCN8ASCN10A
SCHEMBL30712385 0.84 SCN8A (0.44) SCN8ASCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112955436-B 6-oxo-1, 6-dihydropyridazine derivatives, preparation method and application thereof in medicines 福建盛迪医药有限公司 2023-08-11 CN disclosed
EP-3907218-A1 6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Jiangsu Hengrui Medicine Co., Ltd. (CN) 2021-11-10 EP disclosed
CN-112955436-A 6-oxo-1, 6-dihydropyridazine derivatives, preparation method and application thereof in medicines 江苏恒瑞医药股份有限公司 2021-06-11 CN disclosed
WO-2020140959-A1 6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2020-07-09 WO disclosed