Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19926001 | 0.88 | ADORA1 (0.44) | PARP1TNKS2PARP2ADORA1USP30 | |
| SCHEMBL23199846 | 0.80 | PARP1 (0.47) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL23202660 | 0.79 | ADORA1 (0.48) | PARP1TNKS2PARP2ADORA1ESR2 | |
| SCHEMBL23202653 | 0.76 | RAF1 (0.40) | PARP1TNKS2PARP2USP30ESR2 | |
| SCHEMBL8252594 | 0.74 | ADORA1 (0.42) | PARP1TNKS2PARP2ADORA1USP30 | |
| SCHEMBL2118147 | 0.74 | ESR2 (0.46) | PARP1TNKS2PARP2ADORA1USP30 | |
| SCHEMBL29644427 | 0.74 | ESR2 (0.46) | PARP1TNKS2PARP2ADORA1USP30 | |
| SCHEMBL22787765 | 0.74 | ESR2 (0.38) | ADORA1USP30ESR2NR1H2MAPT | |
| SCHEMBL29522675 | 0.74 | ESR2 (0.38) | ADORA1USP30ESR2NR1H2MAPT | |
| SCHEMBL38653270 | 0.73 | ESR2 (0.41) | PARP1TNKS2PARP2ADORA1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507289-B1 | MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LTD (IN) | 2020-07-15 | — | — | EP | disclosed |