Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | KRAS | P01116 | 12/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.39 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.39 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.39 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22220654 | 0.91 | CNR1 (0.51) | CNR1CNR2KRASKITCKS1B | |
| SCHEMBL29889808 | 0.89 | KRAS (0.43) | CNR1CNR2KRASCKS1BSKP1 | |
| SCHEMBL27094339 | 0.89 | KRAS (0.43) | CNR1CNR2KRASCKS1BSKP1 | |
| SCHEMBL27094419 | 0.89 | KRAS (0.44) | CNR1CNR2KRASCKS1BSKP1 | |
| SCHEMBL29889590 | 0.89 | KRAS (0.44) | CNR1CNR2KRASCKS1BSKP1 | |
| SCHEMBL22220629 | 0.89 | KRAS (0.43) | CNR1CNR2KRAS | |
| SCHEMBL22220540 | 0.89 | KRAS (0.43) | CNR1CNR2KRAS | |
| SCHEMBL22586931 | 0.89 | CNR1 (0.46) | CNR1CNR2KRASKITCKS1B | |
| SCHEMBL22220621 | 0.88 | KRAS (0.46) | CNR2KRASEGFRHMOX2CRYZ | |
| SCHEMBL27094374 | 0.88 | KRAS (0.44) | CNR1CNR2KRASCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548888-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| US-11548888-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20200331911-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2020-10-22 | — | — | US | disclosed |
| US-20200331911-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2020-10-22 | — | — | US | disclosed |
| WO-2020146613-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548888-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | CNR1 2951/4885CNR2 3784/4885KRAS 1/4885 |
| US-20200331911-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | CNR1 2951/4885CNR2 3784/4885KRAS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.