Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 12/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22223435 | 1.00 | FOLH1 (0.41) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL22223438 | 0.90 | FOLH1 (0.40) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL24589101 | 0.90 | FOLH1 (0.39) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL24589100 | 0.89 | FOLH1 (0.39) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL22223335 | 0.89 | FOLH1 (0.43) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL22223311 | 0.87 | FOLH1 (0.44) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL24589067 | 0.83 | FOLH1 (0.36) | FOLH1SMN1; SMN2HPGDHTTALDH1A1 | |
| SCHEMBL24588972 | 0.82 | PTGS1 (0.42) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL24589216 | 0.82 | FOLH1 (0.39) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD | |
| SCHEMBL22223369 | 0.82 | FOLH1 (0.39) | FOLH1ITGB3ITGA2BSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146521-A2 | RNAI AGENTS FOR INHIBITING EXPRESSION OF HIF-2 ALPHA (EPAS1), COMPOSITIONS THEREOF, AND METHODS OF USE | Arrowhead Pharmaceuticals, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |