⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235347 | 0.89 | PDE4D (0.30) | — | |
| SCHEMBL22235348 | 0.89 | PDE4D (0.30) | — | |
| SCHEMBL22235351 | 0.89 | PDE4D (0.30) | — | |
| SCHEMBL29728910 | 0.89 | PDE4D (0.30) | — | |
| SCHEMBL22235664 | 0.82 | PDE4D (0.32) | — | |
| SCHEMBL22236197 | 0.71 | NPC1 (0.32) | — | |
| SCHEMBL22235213 | 0.71 | NPC1 (0.32) | — | |
| SCHEMBL22235658 | 0.70 | PDE4D (0.35) | — | |
| SCHEMBL22235214 | 0.68 | KDM4E (0.32) | — | |
| SCHEMBL22235212 | 0.68 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911653-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020150366-A1 | SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-07-23 | — | — | WO | disclosed |