Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 19/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891498 | 0.94 | CHRM1 (0.50) | CHRM1PDE2APDE11A | |
| SCHEMBL2347965 | 0.92 | CHRM1 (0.48) | CHRM1PDE2APDE11A | |
| SCHEMBL2225836 | 0.88 | CHRM1 (0.51) | CHRM1PDE2APDE11A | |
| SCHEMBL2222400 | 0.87 | CHRM1 (0.54) | CHRM1PDE2APDE11A | |
| SCHEMBL2352500 | 0.85 | CHRM1 (0.54) | CHRM1PDE2APDE11A | |
| SCHEMBL12803052 | 0.84 | CHRM1 (0.46) | CHRM1PDE2APDE11A | |
| SCHEMBL17296541 | 0.83 | CHRM1 (0.50) | CHRM1 | |
| SCHEMBL2223721 | 0.83 | CHRM1 (0.44) | CHRM1PDE2APDE11A | |
| SCHEMBL12803346 | 0.83 | CHRM1 (0.54) | CHRM1PDE2APDE11A | |
| SCHEMBL2224239 | 0.82 | CHRM1 (0.56) | CHRM1PDE2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |