Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 20/20 | 0.85 |
| ▸ | DLK1 | P80370 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239529 | 0.93 | MAP3K12 (0.77) | MAP3K12DLK1 | |
| SCHEMBL16220393 | 0.92 | MAP3K12 (1.00) | MAP3K12DLK1 | |
| SCHEMBL16220469 | 0.91 | MAP3K12 (1.00) | MAP3K12DLK1 | |
| SCHEMBL16220275 | 0.90 | MAP3K12 (1.00) | MAP3K12DLK1 | |
| SCHEMBL22239451 | 0.90 | MAP3K12 (0.84) | MAP3K12DLK1 | |
| SCHEMBL16220241 | 0.89 | MAP3K12 (0.83) | MAP3K12DLK1 | |
| SCHEMBL16220397 | 0.89 | MAP3K12 (0.90) | MAP3K12DLK1 | |
| SCHEMBL16220276 | 0.89 | MAP3K12 (0.83) | MAP3K12DLK1 | |
| SCHEMBL16220356 | 0.89 | MAP3K12 (1.00) | MAP3K12DLK1 | |
| SCHEMBL16220036 | 0.89 | MAP3K12 (1.00) | MAP3K12DLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991977-B1 | C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES | HOFFMANN LA ROCHE (CH) | 2020-07-22 | — | — | EP | disclosed |