Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 19/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16220150 | 0.88 | MAP3K12 (0.66) | MAP3K12 | |
| SCHEMBL22239571 | 0.85 | MAP3K12 (0.72) | MAP3K12 | |
| SCHEMBL16220160 | 0.84 | MAP3K12 (0.66) | MAP3K12 | |
| SCHEMBL16220303 | 0.84 | MAP3K12 (0.62) | MAP3K12JAK2JAK3 | |
| SCHEMBL16220155 | 0.81 | MAP3K12 (0.66) | MAP3K12 | |
| SCHEMBL16220060 | 0.78 | MAP3K12 (0.61) | MAP3K12JAK2JAK3 | |
| SCHEMBL16220481 | 0.77 | MAP3K12 (0.52) | MAP3K12 | |
| SCHEMBL22239533 | 0.76 | MAP3K12 (0.57) | MAP3K12 | |
| SCHEMBL16220153 | 0.76 | MAP3K12 (0.52) | MAP3K12 | |
| SCHEMBL16220028 | 0.74 | MAP3K12 (0.78) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991977-B1 | C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES | HOFFMANN LA ROCHE (CH) | 2020-07-22 | — | — | EP | disclosed |