Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.43 |
| ▸ | WNT1 | P04628 | 14/20 | 0.43 |
| ▸ | GSK3B | P49841 | 13/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714022 | 0.86 | DYRK1A (0.41) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17768270 | 0.80 | DYRK1A (0.43) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17767959 | 0.77 | DYRK1A (0.42) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17618869 | 0.77 | DYRK1A (0.42) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19714027 | 0.76 | DYRK1A (0.39) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17618859 | 0.75 | DYRK1A (0.40) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19714327 | 0.75 | DYRK1A (0.41) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19699109 | 0.75 | DYRK1A (0.39) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL17778891 | 0.75 | DYRK1A (0.40) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19714065 | 0.74 | DYRK1A (0.40) | DYRK1AWNT1GSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |