Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 5/20 | 0.32 |
| ▸ | RAF1 | P04049 | 3/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770131 | 1.00 | SCN9A (0.33) | SCN9ASCN10ACNR2RAF1CTSS | |
| SCHEMBL19714029 | 1.00 | SCN9A (0.33) | SCN9ASCN10ACNR2RAF1CTSS | |
| SCHEMBL19713711 | 1.00 | SCN9A (0.33) | SCN9ASCN10ACNR2RAF1CTSS | |
| SCHEMBL17770137 | 1.00 | SCN9A (0.33) | SCN9ASCN10ACNR2RAF1CTSS | |
| SCHEMBL19713712 | 1.00 | SCN9A (0.33) | SCN9ASCN10ACNR2RAF1CTSS | |
| SCHEMBL19736546 | 0.90 | SCN9A (0.31) | SCN9ASCN10ACNR2CTSSACACB | |
| SCHEMBL19713929 | 0.89 | CNR2 (0.36) | CNR2AXL | |
| SCHEMBL19713927 | 0.89 | CNR2 (0.36) | CNR2AXL | |
| SCHEMBL19736200 | 0.89 | CNR2 (0.38) | CNR2 | |
| SCHEMBL19736350 | 0.88 | ACACB (0.34) | SCN9ASCN10ACTSSACACBJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |