Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277746 | 0.92 | JAK1 (0.45) | JAK1JAK2HTR6HTR2ATYK2 | |
| SCHEMBL2278047 | 0.91 | JAK2 (0.44) | JAK1JAK2HTR6HTR2ATYK2 | |
| SCHEMBL12384876 | 0.90 | JAK1 (0.46) | JAK1JAK2HTR6HTR2ATYK2 | |
| SCHEMBL2279733 | 0.89 | JAK1 (0.60) | JAK1JAK2HTR6HTR2AJAK3 | |
| SCHEMBL2278455 | 0.89 | JAK1 (0.44) | JAK1JAK2HTR6HTR2ATYK2 | |
| SCHEMBL2271087 | 0.88 | JAK1 (0.45) | JAK1JAK2HTR6TYK2JAK3 | |
| SCHEMBL2271047 | 0.88 | JAK1 (0.52) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2278611 | 0.87 | JAK1 (0.41) | JAK1JAK2HTR6HTR2ATYK2 | |
| SCHEMBL2278249 | 0.87 | JAK1 (0.43) | JAK1JAK2HTR6TYK2JAK3 | |
| SCHEMBL2276322 | 0.87 | JAK1 (0.45) | JAK1JAK2HTR6TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |