Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.62 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224681 | 0.84 | HDAC6 (0.60) | HDAC6HDAC1 | |
| SCHEMBL896466 | 0.77 | HDAC6 (1.00) | HDAC6 | |
| SCHEMBL15725412 | 0.74 | HDAC6 (0.84) | HDAC6 | |
| SCHEMBL6879907 | 0.74 | HDAC6 (0.77) | HDAC6 | |
| SCHEMBL2228180 | 0.74 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL15725403 | 0.72 | HDAC6 (0.84) | HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL6879260 | 0.71 | HDAC6 (0.51) | HDAC6SIRT5HDAC3HDAC1HDAC2 | |
| SCHEMBL6878592 | 0.69 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL2225590 | 0.66 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL2229659 | 0.64 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734500-A2 | HISTONE DEACETYLASE 6 SELECTIVE INHIBITORS FOR THE TREATMENT OF BONE DISEASE | The General Hospital Corporation (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013013113-A2 | HISTONE DEACETYLASE 6 SELECTIVE INHIBITORS FOR THE TREATMENT OF BONE DISEASE | THE GENERAL HOSPITAL CORPORATION (US) | 2013-01-24 | — | — | WO | disclosed |
| WO-2011091213-A2 | REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | ACETYLON PHARMACEUTICALS (US) | 2011-07-28 | — | — | WO | disclosed |