Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 7/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22245255 | 1.00 | CYP1A1 (0.51) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22232972 | 1.00 | CYP1A1 (0.51) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22230855 | 0.92 | CYP1A1 (0.52) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22230858 | 0.92 | CYP1A1 (0.52) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22244891 | 0.90 | ABCB1 (0.49) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL24605428 | 0.88 | CYP1A1 (0.46) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22245048 | 0.88 | CYP1A1 (0.46) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL24605429 | 0.88 | CYP1A1 (0.46) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL24605947 | 0.86 | CSNK2A2 (0.44) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL22230959 | 0.86 | HPGD (0.47) | CYP1A1CYP1B1CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213049-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2022-07-07 | — | — | US | disclosed |
| WO-2020148354-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213049-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HAVCR2, CYP26B1, CYP7A1 | CYP1A1 18/4885CYP1B1 9/4885CSNK2A2 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.