Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.44 |
| ▸ | RB1 | P06400 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20794683 | 0.84 | BCHE (0.45) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL6618122 | 0.81 | GRIN2B (0.50) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL29324146 | 0.81 | GRIN2B (0.47) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL29081462 | 0.81 | GRIN2B (0.47) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL25176271 | 0.78 | TSHR (0.58) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL658055 | 0.78 | GRIN2B (0.62) | GRIN2BACHEBACE1BCHEMEN1 | |
| Hydrochloric Acid SCHEMBL5238529 | 0.76 | GRIN2B (0.61) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL13280563 | 0.75 | GRIN2B (0.59) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL25524794 | 0.75 | GRIN2B (0.55) | GRIN2BACHEBACE1BCHEMEN1 | |
| SCHEMBL16254267 | 0.75 | GRIN2B (0.59) | GRIN2BACHEBACE1BCHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |